Immobilization of glucose oxidase on synthetic and biological materials for biosensor development

A biosensor is described as a compact analytical device, incorporating a biological or biologically derived sensing element, either closely connected to, or integrated within, a transducer system. The principle of detection is the specific binding of the analyte of interest to the complementary biorecognition element immobilized on a suitable support matrix. The specific interaction results in a change in one or more physico-chemical properties (pH change, electron transfer, mass change, heat transfer, uptake or release of gases or specific ions) which are detected and may be measured by the transducer. The usual aim is to produce an electronic signal, which is proportional in magnitude or frequency to the concentration of a specific analyte or group of analytes, to which the biosensing element binds (1-2). Abstract